High-resolution TADs reveal DNA sequences underlying genome organization in flies

Fidel Ramírez; Vivek Bhardwaj; Laura Arrigoni; Kin Chung Lam; Björn A. Grüning; José Villaveces; Bianca Habermann; Asifa Akhtar; Thomas Manke

doi:10.1038/s41467-017-02525-w

Nature Communications (Jan 2018)

High-resolution TADs reveal DNA sequences underlying genome organization in flies

Fidel Ramírez,
Vivek Bhardwaj,
Laura Arrigoni,
Kin Chung Lam,
Björn A. Grüning,
José Villaveces,
Bianca Habermann,
Asifa Akhtar,
Thomas Manke

Affiliations

Fidel Ramírez: Max Planck Institute of Immunobiology and Epigenetics
Vivek Bhardwaj: Max Planck Institute of Immunobiology and Epigenetics
Laura Arrigoni: Max Planck Institute of Immunobiology and Epigenetics
Kin Chung Lam: Max Planck Institute of Immunobiology and Epigenetics
Björn A. Grüning: University of Freiburg, Department of Computer Science
José Villaveces: Max Planck Institute of Biochemistry and Computational Biology
Bianca Habermann: Max Planck Institute of Biochemistry and Computational Biology
Asifa Akhtar: Max Planck Institute of Immunobiology and Epigenetics
Thomas Manke: Max Planck Institute of Immunobiology and Epigenetics

DOI: https://doi.org/10.1038/s41467-017-02525-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Although topologically associating domains (TADs) have been extensively investigated, it is not clear to what extent DNA sequence contributes to their formation. Here the authors develop software to identify high-resolution TAD boundaries and reveal their relationship to underlying DNA motifs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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