How intrauterine growth restriction due to nutritional stress changes the function of key proteins in brain serotonin metabolism during development

Abstract

This review aimed to describe and comment on how experimental intrauterine nutritional stress in animals produced some changes in tryptophan-5-hydroxylases (TPH) 1 and 2 in the brain and other key proteins such as plasma albumin, and how the intrauterine nutritional stress could produce long-lasting alterations in serotonin function in the brain of human infants.

Keywords

• rauterine growth restriction. Undernourishment. Serotonin neurons. Tryptophan-5-hydroxylases. Plasma albumin.