COGNITIVE-MNESTIC FUNCTIONS IN ABLE-BODIED AGED PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION IN AMLODIPINE TREATMENT

Abstract

Aim. To evaluate an effect of amlodipine on cognitive-mnestic functions (CMF) in able-bodied aged patients with essential arterial hypertension (EHT) with different degrees of blood pressure (BP) elevation. Material and Methods. CMF were studied in 97 patients with EAH aged 30-60 before and after antihypertensive therapy with amlodipine. Results. Revealed CMF changes corresponded to amnestic multifunctional type of mild cognitive impairments (R. Peterson, 2004) that is considered as a precursor of vascular dementia. Cognitive deficiency grade correlated positively with BP elevation degree: a total MMSE score is higher in patients with EHT 1 degree than this in patients with EHT 3 degree. Amlodipine therapy improved CMF: total MMSE score increased as well as scores according to “Attention” and “Memory” scales of MMSE. Conclusion. Monotherapy with calcium channels antagonist, amlodipine, improves CMF in patients with EAH. Amlodipine has positive effects on attention concentration and memory.

Keywords

• essential arterial hypertension
• cognitive-mnestic functions
• amlodipine