Involvement of Histamine Released From Mast Cells in Acute Radiation Dermatitis in Mice

Saiko Moriyasu; Kouichi Yamamoto; Naoko Kureyama; Keita Okamura; Toshiji Ikeda; Atsushi Yamatodani

Journal of Pharmacological Sciences (Jan 2007)

Involvement of Histamine Released From Mast Cells in Acute Radiation Dermatitis in Mice

Saiko Moriyasu,
Kouichi Yamamoto,
Naoko Kureyama,
Keita Okamura,
Toshiji Ikeda,
Atsushi Yamatodani

Affiliations

Saiko Moriyasu: Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan
Kouichi Yamamoto: Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan; Corresponding author. [email protected]
Naoko Kureyama: Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan
Keita Okamura: Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan
Toshiji Ikeda: Department of Accelerator Science, The Institute of Scientific and Industrial Research, Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan
Atsushi Yamatodani: Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Yamadaoka 1-7, Suita, Osaka 565-0871, Japan

Journal volume & issue: Vol. 104, no. 2
pp. 187 – 190

Abstract

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A possible involvement of histamine in acute radiation dermatitis in mice was investigated. The dose of 40 Gy of gamma irradiation induced erythema and edema in C57BL/6 mice treated with vehicle. However, in C57BL/6 mice treated with chlorpheniramine and WBB6F1-W/Wv mice, erythema and edema were not observed. In all of these mice, epilation and dry desquamation were induced, but bepotastine significantly reduced the extent of these areas. These results suggest that gamma irradiation-induced erythema and edema were caused by histamine released from mast cells via histamine H1 receptor, and epilation was induced by other inflammatory mediators. Keywords:: radiation dermatitis, histamine, mast cell

Published in Journal of Pharmacological Sciences

ISSN: 1347-8613 (Print)
Publisher: Elsevier
Country of publisher: Japan
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://www.journals.elsevier.com/journal-of-pharmacological-sciences

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