Nature Communications (Nov 2018)
Adipocyte OGT governs diet-induced hyperphagia and obesity
- Min-Dian Li,
- Nicholas B. Vera,
- Yunfan Yang,
- Bichen Zhang,
- Weiming Ni,
- Enida Ziso-Qejvanaj,
- Sheng Ding,
- Kaisi Zhang,
- Ruonan Yin,
- Simeng Wang,
- Xu Zhou,
- Ethan X. Fang,
- Tian Xu,
- Derek M. Erion,
- Xiaoyong Yang
Affiliations
- Min-Dian Li
- Program in Integrative Cell Signaling and Neurobiology of Metabolism and Department of Comparative Medicine, Yale University School of Medicine
- Nicholas B. Vera
- Cardiovascular, Metabolic & Endocrine Disease Research Unit, Pfizer Worldwide Research & Development
- Yunfan Yang
- Program in Integrative Cell Signaling and Neurobiology of Metabolism and Department of Comparative Medicine, Yale University School of Medicine
- Bichen Zhang
- Program in Integrative Cell Signaling and Neurobiology of Metabolism and Department of Comparative Medicine, Yale University School of Medicine
- Weiming Ni
- Program in Integrative Cell Signaling and Neurobiology of Metabolism and Department of Comparative Medicine, Yale University School of Medicine
- Enida Ziso-Qejvanaj
- Cardiovascular, Metabolic & Endocrine Disease Research Unit, Pfizer Worldwide Research & Development
- Sheng Ding
- Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine
- Kaisi Zhang
- Program in Integrative Cell Signaling and Neurobiology of Metabolism and Department of Comparative Medicine, Yale University School of Medicine
- Ruonan Yin
- Program in Integrative Cell Signaling and Neurobiology of Metabolism and Department of Comparative Medicine, Yale University School of Medicine
- Simeng Wang
- Program in Integrative Cell Signaling and Neurobiology of Metabolism and Department of Comparative Medicine, Yale University School of Medicine
- Xu Zhou
- Department of Immunobiology, Yale University School of Medicine
- Ethan X. Fang
- Department of Statistics, Pennsylvania State University
- Tian Xu
- Department of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine
- Derek M. Erion
- Cardiovascular, Metabolic & Endocrine Disease Research Unit, Pfizer Worldwide Research & Development
- Xiaoyong Yang
- Program in Integrative Cell Signaling and Neurobiology of Metabolism and Department of Comparative Medicine, Yale University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-07461-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Endocannabinoid signaling regulates food intake and is a potential therapeutic target for obesity. Here the authors show that adipocyte O-GlcNAc transferase (OGT) is required for high fat diet-induced hyperphagia via transcriptional activation of de novo lipid desaturation and accumulation of an endogenous appetite-inducing cannabinoid.
