BLOOD CONCENTRATIONS OF NITRITE/NITRATE (NOx), METHEMOGLOBIN, LACTATE AND THEIR CORRELATION IN PATIENS AFTER LUNG TRANSPLANTATION DURING TREATMENT WITH INHALED NITRIC OXIDE

M. Sh. Khubutiya; M. M. Abakumov; E. V. Klychnikova; E. A. Tarabrin; E. V. Tazina; M. A. Godkov; A. A. Romanov; O. A. Kurilova; E. I. Pervakova; D. Kh. Tsurova

doi:10.15825/1995-1191-2013-3-38-43

Vestnik Transplantologii i Iskusstvennyh Organov (Oct 2013)

BLOOD CONCENTRATIONS OF NITRITE/NITRATE (NOx), METHEMOGLOBIN, LACTATE AND THEIR CORRELATION IN PATIENS AFTER LUNG TRANSPLANTATION DURING TREATMENT WITH INHALED NITRIC OXIDE

M. Sh. Khubutiya,
M. M. Abakumov,
E. V. Klychnikova,
E. A. Tarabrin,
E. V. Tazina,
M. A. Godkov,
A. A. Romanov,
O. A. Kurilova,
E. I. Pervakova,
D. Kh. Tsurova

Affiliations

M. Sh. Khubutiya: Sklifosovsky Research Institute for Emergency Medicine Health Department of Moscow (director – corresponding-member of RAMSci, prof. Khubutiya M.S.), Moscow, Russian Federation
M. M. Abakumov: Sklifosovsky Research Institute for Emergency Medicine Health Department of Moscow (director – corresponding-member of RAMSci, prof. Khubutiya M.S.), Moscow, Russian Federation
E. V. Klychnikova: Sklifosovsky Research Institute for Emergency Medicine Health Department of Moscow (director – corresponding-member of RAMSci, prof. Khubutiya M.S.), Moscow, Russian Federation
E. A. Tarabrin: Sklifosovsky Research Institute for Emergency Medicine Health Department of Moscow (director – corresponding-member of RAMSci, prof. Khubutiya M.S.), Moscow, Russian Federation
E. V. Tazina: Sklifosovsky Research Institute for Emergency Medicine Health Department of Moscow (director – corresponding-member of RAMSci, prof. Khubutiya M.S.), Moscow, Russian Federation
M. A. Godkov: Sklifosovsky Research Institute for Emergency Medicine Health Department of Moscow (director – corresponding-member of RAMSci, prof. Khubutiya M.S.), Moscow, Russian Federation
A. A. Romanov: Sklifosovsky Research Institute for Emergency Medicine Health Department of Moscow (director – corresponding-member of RAMSci, prof. Khubutiya M.S.), Moscow, Russian Federation
O. A. Kurilova: Sklifosovsky Research Institute for Emergency Medicine Health Department of Moscow (director – corresponding-member of RAMSci, prof. Khubutiya M.S.), Moscow, Russian Federation
E. I. Pervakova: Sklifosovsky Research Institute for Emergency Medicine Health Department of Moscow (director – corresponding-member of RAMSci, prof. Khubutiya M.S.), Moscow, Russian Federation
D. Kh. Tsurova: Sklifosovsky Research Institute for Emergency Medicine Health Department of Moscow (director – corresponding-member of RAMSci, prof. Khubutiya M.S.), Moscow, Russian Federation

DOI: https://doi.org/10.15825/1995-1191-2013-3-38-43
Journal volume & issue: Vol. 15, no. 3
pp. 38 – 43

Abstract

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Aim. The purpose of the research was correlation analysis of iNO, blood levels of NOx, MetHb and lacta- te in patients after LT. Materials and methods. The duration of iNO therapy was ranged from 2 to 4 days, the data of LT were analyzed in 7 patients. Results. There was a significant increase of NOx and lac- tate levels from 1 to 5 days after operation while the concentration of MetHb remained within the normal range. We have found significant positive correlations in patients after LT: between iNO and NOx concen- tration, iNO and MetHb concentration, iNO and lactate concentration, the concentration of NOx and Me- tHb, the concentration of NOx and lactate, the concentration of MetHb and lactate. Conclusion. The ob- tained data indicate that during application of iNO in patients with LT it is necessary to control both the concentration of administered iNO, the concentration of MetHb in blood and the level of NOx in serum.

Published in Vestnik Transplantologii i Iskusstvennyh Organov

ISSN: 1995-1191 (Print)
Publisher: Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
Country of publisher: Russian Federation
LCC subjects: Medicine: Surgery
Website: http://journal.transpl.ru/

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