SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition

Daniel M. Altmann; Catherine J. Reynolds; Rosemary J. Boyton

Cell Reports Medicine (May 2021)

SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition

Daniel M. Altmann,
Catherine J. Reynolds,
Rosemary J. Boyton

Affiliations

Daniel M. Altmann: Department of Immunology and Inflammation, Imperial College London, London, UK; Corresponding author
Catherine J. Reynolds: Department of Infectious Disease, Imperial College London, London, UK
Rosemary J. Boyton: Department of Infectious Disease, Imperial College London, London, UK; Lung Division, Royal Brompton Hospital and Harefield Hospitals, London, UK; Corresponding author

Journal volume & issue: Vol. 2, no. 5
p. 100286

Abstract

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COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss or gain of predicted epitopes depending on HLA type.

Published in Cell Reports Medicine

ISSN: 2666-3791 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General)
Website: https://www.cell.com/cell-reports-medicine

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