Cancer Medicine (Jun 2021)
Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan
- Chikatoshi Katada,
- Manabu Muto,
- Satoshi Fujii,
- Tetsuji Yokoyama,
- Tomonori Yano,
- Akihito Watanabe,
- Toshiro Iizuka,
- Shigetaka Yoshinaga,
- Ichiro Tateya,
- Hiroki Mitani,
- Yuichi Shimizu,
- Akiko Takahashi,
- Tomoyuki Kamijo,
- Noboru Hanaoka,
- Makoto Abe,
- Akihiro Shiotani,
- Koichi Kano,
- Yukinori Asada,
- Tamotsu Matsuhashi,
- Hirohito Umeno,
- Kenji Okami,
- Kenichi Goda,
- Shinichiro Hori,
- Yoichiro Ono,
- Shuji Terai,
- Yasuaki Nagami,
- Kenichi Takemura,
- Kenro Kawada,
- Mizuo Ando,
- Naoto Shimeno,
- Akihito Arai,
- Yasutoshi Sakamoto,
- Masaaki Ichinoe,
- Tetsuo Nemoto,
- Masahiro Fujita,
- Hidenobu Watanabe,
- Tadakazu Shimoda,
- Atsushi Ochiai,
- Takakuni Kato,
- Ryuichi Hayashi
Affiliations
- Chikatoshi Katada
- Department of Gastroenterology Kitasato University School of Medicine Sagamihara Japan
- Manabu Muto
- Department of Therapeutic Oncology Kyoto University Graduate School of Medicine Kyoto Japan
- Satoshi Fujii
- Department of Molecular Pathology Yokohama City University School of Medicine Yokohama Japan
- Tetsuji Yokoyama
- Department of Health Promotion National Institute of Public Health Wako Japan
- Tomonori Yano
- Department of Gastroenterology and Endoscopy National Cancer Center Hospital East Kashiwa Japan
- Akihito Watanabe
- Department of Otolaryngology Keiyukai Sapporo Hospital Sapporo Japan
- Toshiro Iizuka
- Department of Gastroenterology Toranomon Hospital Tokyo Japan
- Shigetaka Yoshinaga
- Endoscopy Division National Cancer Center Hospital Tokyo Japan
- Ichiro Tateya
- Department of Otolaryngology ‐ Head and Neck Surgery Kyoto University Kyoto Japan
- Hiroki Mitani
- Department of Head and Neck Oncology Cancer Institute Hospital Tokyo Japan
- Yuichi Shimizu
- Division of Endoscopy Hokkaido University Hospital Sapporo Japan
- Akiko Takahashi
- Department of Endoscopy Saku Central Hospital Advanced Care Center Saku Japan
- Tomoyuki Kamijo
- Division of Head and Neck Surgery Shizuoka Cancer Center Nagaizumi Japan
- Noboru Hanaoka
- Department of Gastrointestinal Oncology Osaka International Cancer Institute Osaka Japan
- Makoto Abe
- Department of Gastroenterology and Hepatology Okayama University Graduate School Okayama Japan
- Akihiro Shiotani
- Department of Otolaryngology‐Head and Neck Surgery National Defense Medical College Tokorozawa Japan
- Koichi Kano
- Department of Otorhinolaryngology ‐ Head and Neck Surgery Kitasato University School of Medicine Sagamihara Japan
- Yukinori Asada
- Department of Head and Neck Surgery Miyagi Cancer Center Natori Japan
- Tamotsu Matsuhashi
- Department of Gastroenterology Akita University School of Medicine Akita Japan
- Hirohito Umeno
- Department of Otolaryngology‐ Head and Neck Surgery Kurume University School of Medicine Kurume Japan
- Kenji Okami
- Department of Otolaryngology‐ Head and Neck Surgery Tokai University Isehara Japan
- Kenichi Goda
- Department of Endoscopy The Jikei University School of Medicine Tokyo Japan
- Shinichiro Hori
- Department of Endoscopy NHO Shikoku Cancer Center Matsuyama Japan
- Yoichiro Ono
- Department of Gastroenterology Fukuoka University Chikushi Hospital Chikushino Japan
- Shuji Terai
- Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University Niigata Japan
- Yasuaki Nagami
- Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan
- Kenichi Takemura
- Department of Gastroenterology Ishikawa Prefectural Central Hospital Kanazawa Japan
- Kenro Kawada
- Department of Gastrointestinal Surgery Tokyo Medical and Dental University Tokyo Japan
- Mizuo Ando
- Department of Otolaryngology ‐ Head and Neck Surgery Graduate School of Medicine University of Tokyo Tokyo Japan
- Naoto Shimeno
- Department of Gastroenterology Kobe City Medical Center General Hospital Kobe Japan
- Akihito Arai
- Department of Otolaryngology‐Head and Neck Surgery Kyoto Prefectural University of Medicine Kyoto Japan
- Yasutoshi Sakamoto
- Kitasato Clinical Research Center Kitasato University School of Medicine Sagamihara Japan
- Masaaki Ichinoe
- Department of Pathology Kitasato University School of Medicine Sagamihara Japan
- Tetsuo Nemoto
- Department of Diagnostic Pathology Showa University School of MedicineYokohama Northern Hospital Yokohama Japan
- Masahiro Fujita
- Department of Clinical Pathology Sapporo Hokuyu Hospital Sapporo Japan
- Hidenobu Watanabe
- Department of Pathology Pathology and Cytology Laboratories BML INC Tokyo Japan
- Tadakazu Shimoda
- Department of Diagnostic Pathology Shizuoka Cancer Center Nagaizumi Japan
- Atsushi Ochiai
- Exploratory Oncology Research and Clinical Trial Center National Cancer Center Kashiwa Japan
- Takakuni Kato
- Department of Otorhinolaryngology ‐ Head and Neck Surgery The Jikei University School of Medicine Tokyo Japan
- Ryuichi Hayashi
- Department of Head and Neck Surgery National Cancer Center Hospital East Kashiwa Japan
- DOI
- https://doi.org/10.1002/cam4.3927
- Journal volume & issue
-
Vol. 10,
no. 12
pp. 3848 – 3861
Abstract
Abstract Head and neck cancers, especially in hypopharynx and oropharynx, are often detected at advanced stage with poor prognosis. Narrow band imaging enables detection of superficial cancers and transoral surgery is performed with curative intent. However, pathological evaluation and real‐world safety and clinical outcomes have not been clearly understood. The aim of this nationwide multicenter study was to investigate the safety and efficacy of transoral surgery for superficial head and neck cancer. We collected the patients with superficial head and neck squamous cell carcinoma who were treated by transoral surgery from 27 hospitals in Japan. Central pathology review was undertaken on all of the resected specimens. The primary objective was effectiveness of transoral surgery, and the secondary objective was safety including incidence and severity of adverse events. Among the 568 patients, a total of 662 lesions were primarily treated by 575 sessions of transoral surgery. The median tumor diameter was 12 mm (range 1–75) endoscopically. Among the lesions, 57.4% were diagnosed as squamous cell carcinoma in situ. The median procedure time was 48 minutes (range 2–357). Adverse events occurred in 12.7%. Life‐threatening complications occurred in 0.5%, but there were no treatment‐related deaths. During a median follow‐up period of 46.1 months (range 1–113), the 3‐year overall survival rate, relapse‐free survival rate, cause‐specific survival rate, and larynx‐preservation survival rate were 88.1%, 84.4%, 99.6%, and 87.5%, respectively. Transoral surgery for superficial head and neck cancer offers effective minimally invasive treatment. Clinical trials registry number: UMIN000008276.
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