Nature Communications (Mar 2018)

Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis

  • Andrea Mencarelli,
  • Hanif Javanmard Khameneh,
  • Jan Fric,
  • Maurizio Vacca,
  • Sary El Daker,
  • Baptiste Janela,
  • Jing Ping Tang,
  • Sabrina Nabti,
  • Akhila Balachander,
  • Tong Seng Lim,
  • Florent Ginhoux,
  • Paola Ricciardi-Castagnoli,
  • Alessandra Mortellaro

DOI
https://doi.org/10.1038/s41467-018-03495-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Treg cells can maintain intestinal homeostasis and limit intestinal bowel disease. Here the authors use a mouse model of spontaneous colitis to show that calcineurin-NFAT-induced IL-2 production by dendritic cells regulates the balance between Treg and effector T cells in the gut lamina propria.