Atypical Presentation of Antisynthetase Syndrome: A Case Report

Abstract

Antisynthetase syndrome is characterized by autoantibodies against one of many aminoacyl transfer RNA synthetases. The clinical features include interstitial lung disease (ILD), non-erosive arthritis, Raynaud’s phenomenon, myositis, unexplained fever, and/or mechanic’s hands. There is higher incidence of ILD compared to polymyositis or dermatomyositis. Antisynthetase syndrome associated with Pl-7 and Pl-12 antibodies is rare and accounts for less than 10% of all cases. We present a case of 63-year-old lady who presented with only polymyositis without any ILD or other features of antisynthetase syndrome and was positive for anti Pl-7 and anti Pl-12 antibodies.

Keywords

• anti pl-7 antibodies
• anti pl-12 antibodies
• antisynthetase syndrome
• polymyositis