Photoelectric-driven conductive composite ionogel patch for effective wound healing
Xingkai Ju,
Jiao Kong,
Guohua Qi,
Shuping Hou,
Bo Wang,
Xingkang Diao,
Shaojun Dong,
Yongdong Jin
Affiliations
Xingkai Ju
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
Jiao Kong
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
Guohua Qi
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; Corresponding authors.
Shuping Hou
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
Bo Wang
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China
Xingkang Diao
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
Shaojun Dong
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
Yongdong Jin
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China; Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China; Corresponding authors.
Developing the high biosafety, effective and wearable devices for fast wound healing is highly desired but remains a challenge. Here, we propose a “win–win co-operation” strategy to potentiate effective skin wound healing at the wound site by constructing robust and ecofriendly composite patch under opto-electric stimulation. The wearable patch is composed of ionic gel doped with Ti3C2Tx (MXene), which possesses good photothermal response to kill the bacteria via effective inhibition of the expression of inflammatory factors, preventing wound infection. Importantly, the composite ionogel patch is capable of providing green and on-demand electrical stimulation for wound site, guiding cell migration and proliferation by improved bioenergy and expression up-regulation of growth factor. In mice wound models, the treatment group healed ∼31% more rapidly. Mechanistically, the wearable devices could enable visual and real-time supervising treatment effect due to their good transmittance. The proposed strategy would be promising for future clinical treatment of wound healing.
