Research progress in mitochondrial dynamics-related proteins and ischemic stroke

Abstract

Ischemic stroke is a common acute cerebrovascular disease in clinical practice， which poses a severe threat to human health. In recent years， with deepening understanding of ischemic stroke， significant progress has been made in the diagnosis and treatment. However， current treatments for ischemic stroke are partially limited due to extremely complex pathological mechanisms. Studies have shown that mitochondrial dysfunction plays an important role in the pathogenesis of ischemic stroke. Therefore， modulation of mitochondrial function through mitochondrial dynamics is essential to ameliorate the damage of cerebral ischemic neuronal cells. In this article， the molecular mechanism of mitochondrial dynamics and its role in ischemic stroke were reviewed， aiming to provide useful reference for the treatment of ischemic stroke.

Keywords

• ischemia and hypoxia|mitochondrial dynamics|oxidative stress|inflammatory reaction|apoptosis|necroptosis|ferroptosis