GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model

Bradley M. Roberts; Natalie M. Doig; Katherine R. Brimblecombe; Emanuel F. Lopes; Ruth E. Siddorn; Sarah Threlfell; Natalie Connor-Robson; Nora Bengoa-Vergniory; Nicholas Pasternack; Richard Wade-Martins; Peter J. Magill; Stephanie J. Cragg

doi:10.1038/s41467-020-18247-5

Nature Communications (Oct 2020)

GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model

Bradley M. Roberts,
Natalie M. Doig,
Katherine R. Brimblecombe,
Emanuel F. Lopes,
Ruth E. Siddorn,
Sarah Threlfell,
Natalie Connor-Robson,
Nora Bengoa-Vergniory,
Nicholas Pasternack,
Richard Wade-Martins,
Peter J. Magill,
Stephanie J. Cragg

Affiliations

Bradley M. Roberts: Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford
Natalie M. Doig: Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford
Katherine R. Brimblecombe: Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford
Emanuel F. Lopes: Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford
Ruth E. Siddorn: Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford
Sarah Threlfell: Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford
Natalie Connor-Robson: Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford
Nora Bengoa-Vergniory: Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford
Nicholas Pasternack: Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford
Richard Wade-Martins: Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford
Peter J. Magill: Oxford Parkinson’s Disease Centre, University of Oxford
Stephanie J. Cragg: Centre for Integrative Neuroscience, Department of Physiology, Anatomy and Genetics, University of Oxford

DOI: https://doi.org/10.1038/s41467-020-18247-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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GABA transporters expressed in the striatum may affect behaviour. Here the authors investigate the contribution of GABA transporters on astrocytes to the regulation of dopamine release in the striatum, and show decreased expression of GAT-1 and GAT-3 in a mouse model of Parkinsonism.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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