A new lignan and active compounds inhibiting NF-κB signaling pathway from Caulis Trachelospermi

Abstract

A new dibenzylbutyrolactone lignan named matairesinol 4′-O-β-d-cellobioside (1), together with a known compound (7R, 8S)-dihydrodehydrodiconiferyl alcohol (2) was isolated from Caulis Trachelospermi. The extract of Caulis Trachelospermi, which was separated by 80% alcohol extraction and subsequent HP-20 macroporous resin column chromatography, and its main components trachelogenin (3), nortrachelogenin (4), matairesinol (5) showed moderate inhibiting activities on NF-κB signaling pathway induced by TNFα, with the IC50 values of 17.7 μg/mL, 17.9 μM, 49.4 μM and 29.1 μM, respectively.

Keywords

• Caulis Trachelospermi
• Matairesinol 4′-O-β-d-cellobioside
• Dibenzylbutyrolactone lignan
• NF-κB signaling pathway