Nature Communications (Nov 2020)
Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis
- Chi Wang,
- Hui Liu,
- Kun Li,
- Zhen-Zhen Wu,
- Chen Wu,
- Jing-Ying Yu,
- Qian Gong,
- Ping Fang,
- Xing-Xing Wang,
- Shu-Min Duan,
- Hao Wang,
- Yan Gu,
- Ji Hu,
- Bing-Xing Pan,
- Mathias V. Schmidt,
- Yi-Jun Liu,
- Xiao-Dong Wang
Affiliations
- Chi Wang
- Department of Neurobiology and Department of Psychiatry of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Hui Liu
- Department of Neurobiology and Department of Psychiatry of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Kun Li
- Department of Neurobiology and Department of Psychiatry of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Zhen-Zhen Wu
- Department of Neurobiology and Department of Psychiatry of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Chen Wu
- Department of Neurobiology and Department of Psychiatry of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Jing-Ying Yu
- Department of Neurobiology and Department of Psychiatry of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Qian Gong
- Department of Neurobiology and Department of Psychiatry of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Ping Fang
- Department of Neurobiology and Department of Psychiatry of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Xing-Xing Wang
- Department of Anesthesiology, Technische Universität München/Klinikum Rechts der Isar
- Shu-Min Duan
- NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University
- Hao Wang
- NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Research and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University
- Yan Gu
- Center of Stem Cell and Regenerative Medicine, and Department of Neurology of the Second Affiliated Hospital, Zhejiang University School of Medicine
- Ji Hu
- School of Life Science and Technology, ShanghaiTech University
- Bing-Xing Pan
- Laboratory of Fear and Anxiety Disorders, Institute of Life Science, Nanchang University
- Mathias V. Schmidt
- Max Planck Institute of Psychiatry
- Yi-Jun Liu
- Department of Neurobiology and Department of Psychiatry of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Xiao-Dong Wang
- Department of Neurobiology and Department of Psychiatry of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-19874-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Touch can positively modulate cognitive performance and emotional response. Here the authors demonstrate that enriched tactile experience improves memory and reduces anxiety in adult mice by remodelling the pathway from the primary somatosensory cortex to the dentate gyrus.
