Effect of mevalonate analogues upon cholesterol biosynthesis

Herbert Weiss; Elliott Schiffmann; Elwood Titus

Journal of Lipid Research (Jul 1961)

Effect of mevalonate analogues upon cholesterol biosynthesis

Herbert Weiss,
Elliott Schiffmann,
Elwood Titus

Affiliations

Herbert Weiss: Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda 14, Maryland
Elliott Schiffmann: Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda 14, Maryland
Elwood Titus: Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda 14, Maryland

Journal volume & issue: Vol. 2, no. 3
pp. 258 – 262

Abstract

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Three analogues of mevalonic acid have been found to inhibit cholesterol biosynthesis in liver homogenates in the following order of efficacy: 3-methyl-3-hydroxy pentanoic acid > Δ2-3-methyl pentenoic acid > Δ3-3-methyl pentenoic acid. The hydroxy acid produces half the maximum inhibition at a concentration of 5 μmoles/ml of homogenate. This corresponds to a ratio of 100 μmoles of inhibitor to 1 μmole of substrate.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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