Meta-analysis of efficacy evaluation of traditional Chinese medicine combined with Western medicine in the treatment of traumatic optic neuropathy

Abstract

AIM: To evaluate the efficacy and safety of traditional Chinese medicine combined with Western medicine(TCM-WM)in the treatment of traumatic optic neuropathy(TON).METHODS:The computer searched PubMed, EMBASE, Cochrane Library, Chinese Biomedical Literature Database(CBM), Wan-Fang Database, China National Knowledge Infrastructure(CNKI)database and Weipu database. Search time was limited from their inception to May 2020. A comprehensive search strategy was designed to identify all randomized controlled trials(RCTs)comparing TCM-WM therapy versus WM therapy alone. The methodological quality of the included trials was assessed by the quality grade evaluation used in Cochrane handbook. Data extraction and Meta-analysis were performed by RevMan5.3 statistical software.RESULTS: Twelve RCTs were included. The Meta-analysis showed that compared with the WM therapy alone in treating TON, TCM-WM therapy was better in improving the effective rate [RR=1.33, 95% CI(1.23-1.45), P<0.001], visual acuity [MD=0.18,95% CI(0.14-0.23), P<0.001], visual field mean defect [MD=-3.08, 95% CI(-5.20-0.96), P=0.004], P100 lantency [MD=-9.47, 95% CI(-16.37-2.57), P=0.007] as well as P100 amplitude [MD=1.44, 95% CI (0.22-2.66), P=0.02]. Two researches reported the occurrence and treatment of adverse reactions, and the remaining included researches did not report the adverse reactions.CONCLUSION:The TCM-WM therapy in treating TON is more effective compared with the WM therapy alone.

Keywords

• integration of chinese traditional and western medicine
• traumatic optic neuropathy
• meta-analysis
• randomized controlled trials