Cluster of differentiation 147 complex: A putative early predictive biomarker for preeclampsia?

Abstract

Abstract Preeclampsia (PE) occurs only in humans and some non‐human primates, making its pathogenesis difficult to study. The aetiology of PE is mainly caused by a deficiency in trophoblast differentiation and spiral artery remodelling. The angiogenic factor Placental Growth Factor (PlGF) or the ratio of sFlt‐1 to PlGF and cell‐free RNA have been used as the main biomarkers for predicting PE. Now, Lee and colleagues show that the deficiency of cluster of differentiation 147 (CD147) results in preeclampsia pathophysiology. This contribution makes sheds light on PE development and unveils CD147 as a potential biomarker for clinical trials.

Keywords

• CD147
• preeclampsia
• spiral artery remodelling
• trophoblast differentiation