Regulatory T-cells and allogeneic hematopoietic stem cell transplantation

Abstract

The article has summarized the available data about regulatory T cells, describing in-detail the stages of their studying, their development, classification, mechanisms of immunosuppression in general terms and also in the context of allogeneic hematopoietic stem cells transplantation. The effect of immunosuppressive agents on this cell population is considered.The role of regulatory T cells in the pathogenesis of both acute and chronic graft-versus-host disease has been revealed. The possibilities of clinical use of regulatory T cells (including modified regulatory T cells) in the prevention and treatment of these complications are described in detail.

Keywords

• т-регуляторные клетки
• трег
• трансплантация аллогенных гемопоэтических стволовых клеток
• острая реакция «трансплантат против хозяина»
• хроническая реакция «трансплантат против хозяина»