Nature Communications (May 2017)

Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain

  • Eric B. Gibbs,
  • Feiyue Lu,
  • Bede Portz,
  • Michael J. Fisher,
  • Brenda P. Medellin,
  • Tatiana N. Laremore,
  • Yan Jessie Zhang,
  • David S. Gilmour,
  • Scott A. Showalter

DOI
https://doi.org/10.1038/ncomms15233
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

Read online

The RNA polymerase II C-terminal domain acts as a hub to coordinate transcription and nascent mRNA processing. Here the authors identify a phosphorylation-dependent switch in thetrans-to-cisisomerization of proline in the CTD heptad repeats that make those repeats susceptible to further modifications by regulatory enzymes.