Nature Communications (Aug 2016)

Temporal regulation of Lsp1 O-GlcNAcylation and phosphorylation during apoptosis of activated B cells

  • Jung-Lin Wu,
  • Hsin-Yi Wu,
  • Dong-Yan Tsai,
  • Ming-Feng Chiang,
  • Yi-Ju Chen,
  • Shijay Gao,
  • Chun-Cheng Lin,
  • Chun-Hung Lin,
  • Kay-Hooi Khoo,
  • Yu-Ju Chen,
  • Kuo-I. Lin

DOI
https://doi.org/10.1038/ncomms12526
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

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B cell receptor (BCR) activation can trigger signalling causing apoptosis in order to eliminate auto-reactive B cells. Here the authors show that the O-GlcNAcylation and phosphorylation of lymphocyte-specific protein-1 are involved in a switch that regulates the initiation of apoptosis induced by BCR cross-linking.