Nature Communications (Jan 2023)
The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis
- Lu Han,
- Yongxia Wu,
- Kun Fang,
- Sean Sweeney,
- Ulyss K. Roesner,
- Melodie Parrish,
- Khushbu Patel,
- Tom Walter,
- Julia Piermattei,
- Anthony Trimboli,
- Julia Lefler,
- Cynthia D. Timmers,
- Xue-Zhong Yu,
- Victor X. Jin,
- Michael T. Zimmermann,
- Angela J. Mathison,
- Raul Urrutia,
- Michael C. Ostrowski,
- Gustavo Leone
Affiliations
- Lu Han
- Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
- Yongxia Wu
- Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina
- Kun Fang
- Division of Biostatistics, Medical College of Wisconsin
- Sean Sweeney
- Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
- Ulyss K. Roesner
- Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
- Melodie Parrish
- Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
- Khushbu Patel
- Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
- Tom Walter
- Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
- Julia Piermattei
- Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
- Anthony Trimboli
- Medical College of Wisconsin Cancer Center, Medical College of Wisconsin
- Julia Lefler
- Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
- Cynthia D. Timmers
- Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
- Xue-Zhong Yu
- Department of Microbiology and Immunology, Hollings Cancer Center, Medical University of South Carolina
- Victor X. Jin
- Division of Biostatistics, Medical College of Wisconsin
- Michael T. Zimmermann
- Medical College of Wisconsin Cancer Center, Medical College of Wisconsin
- Angela J. Mathison
- Linda T. and John A. Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin
- Raul Urrutia
- Medical College of Wisconsin Cancer Center, Medical College of Wisconsin
- Michael C. Ostrowski
- Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina
- Gustavo Leone
- Medical College of Wisconsin Cancer Center, Medical College of Wisconsin
- DOI
- https://doi.org/10.1038/s41467-022-34464-6
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 12
Abstract
Cancer-associated fibroblasts (CAFs) are the main component of the stroma in pancreatic cancer, but their tissue of origin remains to be defined. Here the authors perform lineage tracing and single cell RNA sequencing in mice and suggest the splanchnic mesenchyme as the tissue of origin for CAFs.
