Investigation of Yellow Fever Virus at the Human–Animal Interface after a Zika Virus Outbreak in Midwest Brazil

Lis Alvarez Baranowski; Helver Gonçalves Dias; Débora Familiar-Macedo; Gilberto Sabino-Santos; Heitor Miraglia Herrera; Renata Dezengrini Slhessarenko; Flávia Barreto dos Santos; Alex Pauvolid-Corrêa

doi:10.3390/microorganisms12030594

Microorganisms (Mar 2024)

Investigation of Yellow Fever Virus at the Human–Animal Interface after a Zika Virus Outbreak in Midwest Brazil

Lis Alvarez Baranowski,
Helver Gonçalves Dias,
Débora Familiar-Macedo,
Gilberto Sabino-Santos,
Heitor Miraglia Herrera,
Renata Dezengrini Slhessarenko,
Flávia Barreto dos Santos,
Alex Pauvolid-Corrêa

Affiliations

Lis Alvarez Baranowski: Laboratório das Interações Vírus-Hospedeiros, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, RJ, Brazil
Helver Gonçalves Dias: Laboratório das Interações Vírus-Hospedeiros, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, RJ, Brazil
Débora Familiar-Macedo: Laboratório das Interações Vírus-Hospedeiros, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, RJ, Brazil
Gilberto Sabino-Santos: Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LO 70112, USA
Heitor Miraglia Herrera: Laboratório de Biologia Parasitária, Programa de Pós-Graduação em Ciências Ambientais e Sustentabilidade Agropecuária, Universidade Católica Dom Bosco (UCDB), Campo Grande 79117-010, MS, Brazil
Renata Dezengrini Slhessarenko: Laboratório de Virologia, Faculdade de Medicina, Universidade Federal de Mato Grosso (UFMT), Cuiabá 78060-900, MT, Brazil
Flávia Barreto dos Santos: Laboratório das Interações Vírus-Hospedeiros, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro 21040-900, RJ, Brazil
Alex Pauvolid-Corrêa: Laboratório de Virologia Veterinária de Viçosa, Departamento de Veterinária, Universidade Federal de Viçosa (UFV), Viçosa 36570-900, MG, Brazil

DOI: https://doi.org/10.3390/microorganisms12030594
Journal volume & issue: Vol. 12, no. 3
p. 594

Abstract

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Following the first report of zika virus in March 2015, Brazil experienced its largest sylvatic yellow fever outbreak between 2016 and 2019. This study aimed to investigate the circulation of yellow fever virus (YFV) in non-human primates (NHPs) and mosquitoes collected in urban parks and other metropolitan areas of midwest Brazil between 2017 and 2018. Whole blood samples from 80 NHPs, including 48 black-tailed marmosets (Mico melanurus) and 2332 mosquitoes from six different genera, were collected in the states of Mato Grosso (MT) and Mato Grosso do Sul (MS) and then tested for YFV by RT-qPCR. Additionally, 23 plasma samples of NHPs were tested for neutralizing antibodies for YFV by a plaque reduction neutralization test (PRNT). No YFV RNA or neutralizing antibodies for YFV were detected in NHPs and mosquitoes from MT and MS. The continuous monitoring of YFV circulation in different species of NHPs and vectors in urban areas is instrumental to quickly assess potentially unknown maintenance cycles of yellow fever at the human–animal interface in Brazil.

Published in Microorganisms

ISSN: 2076-2607 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.mdpi.com/journal/microorganisms

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