A visual circuit related to the parabrachial nucleus for the antipruritic effects of bright light treatment

Zhengfang Hu; Xiaodan Huang; Jianyu Liu; Ziyang Wang; Yue Xi; Yan Yang; Song Lin; Kwok-Fai So; Lu Huang; Qian Tao; Chaoran Ren

Cell Reports (Jun 2024)

A visual circuit related to the parabrachial nucleus for the antipruritic effects of bright light treatment

Zhengfang Hu,
Xiaodan Huang,
Jianyu Liu,
Ziyang Wang,
Yue Xi,
Yan Yang,
Song Lin,
Kwok-Fai So,
Lu Huang,
Qian Tao,
Chaoran Ren

Affiliations

Zhengfang Hu: Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China
Xiaodan Huang: Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China
Jianyu Liu: Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China
Ziyang Wang: Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China
Yue Xi: Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, China
Yan Yang: Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China
Song Lin: Physiology Department, School of Medicine, Jinan University, Guangzhou 510632, China
Kwok-Fai So: Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China; Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China; Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou 510515, China; Key Laboratory of Brain and Cognitive Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
Lu Huang: Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China; Corresponding author
Qian Tao: Department of Rehabilitation Medicine, First Affiliated Hospital of Jinan University, Department of Public Health and Preventive Medicine Psychology, School of Medicine, Jinan University, Guangzhou 510632, China; Corresponding author
Chaoran Ren: Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China; Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China; Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou 510515, China; Corresponding author

Journal volume & issue: Vol. 43, no. 6
p. 114356

Abstract

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Summary: In addition to its role in vision, light also serves non-image-forming visual functions. Despite clinical evidence suggesting the antipruritic effects of bright light treatment, the circuit mechanisms underlying the effects of light on itch-related behaviors remain poorly understood. In this study, we demonstrate that bright light treatment reduces itch-related behaviors in mice through a visual circuit related to the lateral parabrachial nucleus (LPBN). Specifically, a subset of retinal ganglion cells (RGCs) innervates GABAergic neurons in the ventral lateral geniculate nucleus and intergeniculate leaflet (vLGN/IGL), which subsequently inhibit CaMKIIα+ neurons in the LPBN. Activation of both the vLGN/IGL-projecting RGCs and the vLGN/IGL-to-LPBN projections is sufficient to reduce itch-related behaviors induced by various pruritogens. Importantly, we demonstrate that the antipruritic effects of bright light treatment rely on the activation of the retina-vLGN/IGL-LPBN pathway. Collectively, our findings elucidate a visual circuit related to the LPBN that underlies the antipruritic effects of bright light treatment.

CP: Neuroscience

Published in Cell Reports

ISSN: 2211-1247 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: http://www.cell.com/cell-reports/home

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