α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere

Kizhakke M. Sathyan; Daniele Fachinetti; Daniel R. Foltz

doi:10.1038/ncomms14678

Nature Communications (Mar 2017)

α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere

Kizhakke M. Sathyan,
Daniele Fachinetti,
Daniel R. Foltz

Affiliations

Kizhakke M. Sathyan: Department of Biochemistry and Molecular Genetics, University of Virginia
Daniele Fachinetti: Department of Cell Biology and Cancer, Institut Curie, PSL Research University, CNRS
Daniel R. Foltz: Department of Biochemistry and Molecular Genetics, University of Virginia

DOI: https://doi.org/10.1038/ncomms14678
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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Centromeres are chromosomal domains epigenetically specified by the presence of the CENP-A containing nucleosomes that control chromosome segregation. Here the authors show that α-amino trimethylation of CENP-A by the enzyme NRMT is required for centromere function, faithful chromosome segregation and cell survival.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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