Aminoglucósidos: ¿Cuándo y por qué usar en monodosis? Aminoglucoside: when and why should they be administered once a day?

Abstract

Se realizó una revisión bibliográfica para unificar criterios sobre el uso de aminoglucósidos en intervalo extendido o monodosis. Se hizo una intensa búsqueda para encontrar las referencias de los estudios calificados y de los artículos de revisión sobre este tema. Los criterios de selección exigían que fueran estudios clínicos controlados y aleatorios en pacientes adultos, que compararan dosis única versus dosis múltiples, y que la administración de los medicamentos fuera por vía parenteral.Aminoglucosides are a family of antibiotics that are widely used due to their activity against gramnegative bacteria. They are usually administered by intravenous route in multiple daily doses. However, their use have been questioned due to the nephrotoxicity and ototoxicity they produce. Diverse strategies have been proposed to reduce this toxicity, among them, the single daily dosing, in which the same amount of antibiotic is administered once a day. There are different criteria on this regard at present. A bibliographic review was made to unify criteria on the use of aminoglucosides at extended intervals or in a single dose. An intense search was carried out to find references of qualified studies and review articles on this topic. The selection criteria demanded the existence of clinically controlled randomised studies in adult patients that compared the single daily dose with the multiple daily dose, and the administration of drugs by parenteral route. The clinical and microbiological efficiency of the single daily dose was proved, and recommendations were made on this regard.

Keywords

• Monodosis
• aminoglucósidos
• tratamiento antibiótico
• Single daily dose
• aminoglucosides
• antibitoic treatment