GLI transcriptional repression is inert prior to Hedgehog pathway activation

Rachel K. Lex; Weiqiang Zhou; Zhicheng Ji; Kristin N. Falkenstein; Kaleigh E. Schuler; Kathryn E. Windsor; Joseph D. Kim; Hongkai Ji; Steven A. Vokes

doi:10.1038/s41467-022-28485-4

Nature Communications (Feb 2022)

GLI transcriptional repression is inert prior to Hedgehog pathway activation

Rachel K. Lex,
Weiqiang Zhou,
Zhicheng Ji,
Kristin N. Falkenstein,
Kaleigh E. Schuler,
Kathryn E. Windsor,
Joseph D. Kim,
Hongkai Ji,
Steven A. Vokes

Affiliations

Rachel K. Lex: Department of Molecular Biosciences, University of Texas at Austin
Weiqiang Zhou: Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
Zhicheng Ji: Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
Kristin N. Falkenstein: Department of Molecular Biosciences, University of Texas at Austin
Kaleigh E. Schuler: Department of Molecular Biosciences, University of Texas at Austin
Kathryn E. Windsor: Department of Molecular Biosciences, University of Texas at Austin
Joseph D. Kim: Department of Molecular Biosciences, University of Texas at Austin
Hongkai Ji: Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health
Steven A. Vokes: Department of Molecular Biosciences, University of Texas at Austin

DOI: https://doi.org/10.1038/s41467-022-28485-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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GLI repression has been presumed to be the default transcriptional state and important for pre-patterning tissues. Challenging current models, the authors show that GLI3 repression is inert in the limb bud before the onset of Hedgehog signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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