Dymephosphone dermatoprotective activity under reduced blood circulation

Abstract

Dermatoprotective activity (DPA) comparative evaluation of dymephosphone, actovegin, trental and meksidol under reduced blood circulation has been carried out. It has been proved that in experimental mice dymephosphone judging by DPA exceeds actovegin in quality by 2,8 times and is similar to meksidol. At the same time it is 5,2 times is worse than trental; as for its width of therapeutic activion (WTA) it is better than meksidol, trental and actovegin by 5.6, 1.8 and 2.9 times respectively. In experimental rats dymephosphone judging by DPA exceeds actovegin in quality by 3,6 times and is worse than trental and meksidol by 4.7 and 1.3 times respectively; as for the WTA it is better than actovegin, trental and meksidol by 3.8, 2.0, 5.5 times respectively.

Keywords

• кожный лоскут на питающей ножке
• димефосфон
• актовегин
• трентал
• мексидол
• tissue graft on feeding stalk
• dymephosphone
• actovegin
• trental
• meksidol
• dermatoprotective activity