ASPSCR1::TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma

Miwa Tanaka; Surachada Chuaychob; Mizuki Homme; Yukari Yamazaki; Ruyin Lyu; Kyoko Yamashita; Keisuke Ae; Seiichi Matsumoto; Kohei Kumegawa; Reo Maruyama; Wei Qu; Yohei Miyagi; Ryuji Yokokawa; Takuro Nakamura

doi:10.1038/s41467-023-37049-z

Nature Communications (Apr 2023)

ASPSCR1::TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma

Miwa Tanaka,
Surachada Chuaychob,
Mizuki Homme,
Yukari Yamazaki,
Ruyin Lyu,
Kyoko Yamashita,
Keisuke Ae,
Seiichi Matsumoto,
Kohei Kumegawa,
Reo Maruyama,
Wei Qu,
Yohei Miyagi,
Ryuji Yokokawa,
Takuro Nakamura

Affiliations

Miwa Tanaka: Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research
Surachada Chuaychob: Department of Micro Engineering, Graduate School of Engineering, Kyoto University
Mizuki Homme: Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research
Yukari Yamazaki: Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research
Ruyin Lyu: Department of Micro Engineering, Graduate School of Engineering, Kyoto University
Kyoko Yamashita: Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research
Keisuke Ae: Department of Orthopedic Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research
Seiichi Matsumoto: Department of Orthopedic Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research
Kohei Kumegawa: Project for Cancer Epigenomics, The Cancer Institute, Japanese Foundation for Cancer Research
Reo Maruyama: Project for Cancer Epigenomics, The Cancer Institute, Japanese Foundation for Cancer Research
Wei Qu: Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo
Yohei Miyagi: Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute
Ryuji Yokokawa: Department of Micro Engineering, Graduate School of Engineering, Kyoto University
Takuro Nakamura: Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research

DOI: https://doi.org/10.1038/s41467-023-37049-z
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 16

Abstract

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The mechanisms of angiogenesis in alveolar soft part sarcoma (ASPS) remain to be explored. Here, the authors highlight the role of the ASPSCR1::TFE3 fusion in regulating super-enhancer activity during the angiogenic process in ASPS.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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