Colon carcinoma presenting as ovarian metastasis

Paul Geraeds Kemps, MD; Mijke Bol, MD; Ernst Johan Abraham Steller, MD, PhD; Lisa Maria Henrica de Pont, MD; Cynthia Holterhues, MD, PhD; Leander van Gerven, MD; Wendela Kolkman, MD, PhD

Radiology Case Reports (Sep 2021)

Colon carcinoma presenting as ovarian metastasis

Paul Geraeds Kemps, MD,
Mijke Bol, MD,
Ernst Johan Abraham Steller, MD, PhD,
Lisa Maria Henrica de Pont, MD,
Cynthia Holterhues, MD, PhD,
Leander van Gerven, MD,
Wendela Kolkman, MD, PhD

Affiliations

Paul Geraeds Kemps, MD: Department of Gynecology and Obstetrics, Haga Hospital, The Hague, The Netherlands; Leiden University Medical Center, Leiden, The Netherlands; Corresponding Author.
Mijke Bol, MD: Department of Pathology, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands
Ernst Johan Abraham Steller, MD, PhD: Department of Surgery, Netherlands Cancer Institute-Antoni van Leeuwenhoek, Amsterdam, The Netherlands
Lisa Maria Henrica de Pont, MD: Department of Radiology, Haga Hospital, The Hague, The Netherlands
Cynthia Holterhues, MD, PhD: Department of Internal Medicine, Haga Hospital, The Hague, The Netherlands
Leander van Gerven, MD: Department of Internal Medicine, Haga Hospital, The Hague, The Netherlands
Wendela Kolkman, MD, PhD: Department of Gynecology and Obstetrics, Haga Hospital, The Hague, The Netherlands

Journal volume & issue: Vol. 16, no. 9
pp. 2799 – 2803

Abstract

Read online

An adnexal mass is a common gynecological finding. Most adnexal masses are benign neoplasms, especially in premenopausal women. Yet, here we report a premenopausal woman with an adnexal mass that turned out to be an ovarian metastasis from colon cancer. This case emphasizes the importance of considering an ovarian metastasis in patients with (partially) solid adnexal masses and low serum CA125 levels. In addition, we identified the same KRAS mutation in the biopsied liver metastasis and resected right ovarian metastasis. This is in accordance with a previous molecular study of matched tumor pairs/trios of colorectal cancer patients with ovarian metastases, suggesting that mutated KRAS is a universal driver of the metastatic disease in women with KRAS-mutated colorectal cancer with ovarian metastases. More than half of all colorectal cancer patients with ovarian metastases harbor KRAS mutations. Future studies may investigate the efficacy of KRAS inhibitors in the treatment of these patients.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

About the journal

Abstract

Keywords