BMC Gastroenterology (Dec 2012)

Dyspeptic symptoms and delayed gastric emptying of solids in patients with inactive Crohn’s disease

  • Nóbrega Ana Carolina Mello,
  • Ferreira Bruno Roberto Silva,
  • Oliveira Graciela Josué,
  • Sales Kamila Maria Oliveira,
  • Santos Armênio Aguiar,
  • Nobre e Souza Miguel Ângelo,
  • Braga Lúcia Libanês Bessa Campelo,
  • Troncon Luiz Ernesto de Almeida,
  • Souza Marcellus Henrique Loiola Ponte

DOI
https://doi.org/10.1186/1471-230X-12-175
Journal volume & issue
Vol. 12, no. 1
p. 175

Abstract

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Abstract Background Patients with Crohn’s disease (CD) have been shown to present dyspeptic symptoms more frequently than the general population. Some of these symptoms could be related to motility disorders to some degree. Then, we propose to investigate whether gastric emptying of solids in patients with inactive CD is delayed and to determine the relationships between gastric emptying and dyspeptic symptoms in inactive CD. Methods Twenty-six patients with inactive Crohn’s disease, as defined by a Crohn’s Disease Activity Index (CDAI) 13C octanoic acid coupled to a solid meal and answered a validated questionnaire (The Porto Alegre Dyspeptic Symptoms Questionnaire) to assess dyspeptic symptoms. Patients with scores ≥ 6 were considered to have dyspepsia. The control group was composed by 19 age- and sex-matched healthy volunteers. Results Patients with CD had a significantly longer t 1/2 and t lag (p Conclusion Delayed gastric emptying in inactive Crohn’s disease patients seems to be associated with dyspeptic symptoms, particularly vomiting, even without any evidence of gastrointestinal obstruction.

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