Qili Qiangxin (QLQX) capsule as a multi-functional traditional Chinese medicine in treating chronic heart failure (CHF): A review of ingredients, molecular, cellular, and pharmacological mechanisms
Tongxing Wang,
Bin Hou,
Haoran Qin,
Junqing Liang,
Min Shi,
Yanfei Song,
Kun Ma,
Meng Chen,
Huixin Li,
Guoyuan Ding,
Bing Yao,
Zhixin Wang,
Cong Wei,
Zhenhua Jia
Affiliations
Tongxing Wang
National Key Laboratory of Luobing Research and Innovative Chinese Medicine, Shijiazhuang 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang 050035, China
Bin Hou
National Key Laboratory of Luobing Research and Innovative Chinese Medicine, Shijiazhuang 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang 050035, China
Haoran Qin
Department of Integrative Oncology, Changhai Hospital, Naval Military Medical University, Shanghai 200438, China
Junqing Liang
National Key Laboratory of Luobing Research and Innovative Chinese Medicine, Shijiazhuang 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang 050035, China
Min Shi
National Key Laboratory of Luobing Research and Innovative Chinese Medicine, Shijiazhuang 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang 050035, China
Yanfei Song
Key Disciplines of State Administration of TCM for Luobing, Hebei Academy of Interactive Medicine, Shijiazhuang 050035, China; Shijiazhuang Compound Traditional Chinese Medicine Technology Innovation Center, Shijiazhuang 050035, China
Kun Ma
Hebei Provincial Key Laboratory of Luobing, Shijiazhuang 050035, China
Meng Chen
Hebei Provincial Key Laboratory of Luobing, Shijiazhuang 050035, China
Huixin Li
Key Disciplines of State Administration of TCM for Luobing, Hebei Academy of Interactive Medicine, Shijiazhuang 050035, China
Guoyuan Ding
Key Disciplines of State Administration of TCM for Luobing, Hebei Academy of Interactive Medicine, Shijiazhuang 050035, China; Shijiazhuang Compound Traditional Chinese Medicine Technology Innovation Center, Shijiazhuang 050035, China
Bing Yao
Shijiazhuang Compound Traditional Chinese Medicine Technology Innovation Center, Shijiazhuang 050035, China
Zhixin Wang
Shijiazhuang Compound Traditional Chinese Medicine Technology Innovation Center, Shijiazhuang 050035, China
Cong Wei
National Key Laboratory of Luobing Research and Innovative Chinese Medicine, Shijiazhuang 050035, China; Key Laboratory of State Administration of TCM (Cardio-Cerebral Vessel Collateral Disease), Shijiazhuang 050035, China; Hebei Provincial Key Laboratory of Luobing, Shijiazhuang 050035, China; Corresponding author.National Key Laboratory of Luobing Research and Innovative Chinese Medicine, Shijiazhuang 050035, China.
Zhenhua Jia
National Key Laboratory of Luobing Research and Innovative Chinese Medicine, Shijiazhuang 050035, China; Key Disciplines of State Administration of TCM for Luobing, Hebei Academy of Interactive Medicine, Shijiazhuang 050035, China; Corresponding author. Address: No. 238 Tianshan Road, Gaoxin District, Shijiazhuang, Hebei Province, China.
Chronic heart failure (CHF) is a key part of cardiovascular continuum. Under the guidance of the theory of vessel-collateral doctrine, the present study proposes therapeutic benefits of Qili Qiangxin (QLQX) capsules, an innovative Chinese medicine, on chronic heart failure. The studies show that multiple targets of the drug on CHF, including enhancing myocardial systole, promoting urine excretion, inhibiting excessive activation of the neuroendocrine system, preventing ventricular remodeling by inhibiting inflammatory response, myocardial fibrosis, apoptosis and autophagy, enhancing myocardial energy metabolism, promoting angiogenesis, and improving endothelial function. Investigation on the effects and mechanism of the drug is beneficial to the treatment of chronic heart failure (CHF) through multiple targets and/or signaling pathways. Meanwhile, it provides new insights to further understand other refractory diseases in the cardiovascular continuum, and it also has an important theoretical and practical significance in enhancing prevention and therapeutic effect of traditional Chinese medicine for these diseases.
