Nature Communications (Jun 2022)
EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment
- Shilpa Bhatia,
- Diemmy Nguyen,
- Laurel B. Darragh,
- Benjamin Van Court,
- Jaspreet Sharma,
- Michael W. Knitz,
- Miles Piper,
- Sanjana Bukkapatnam,
- Jacob Gadwa,
- Thomas E. Bickett,
- Shiv Bhuvane,
- Sophia Corbo,
- Brian Wu,
- Yichien Lee,
- Mayumi Fujita,
- Molishree Joshi,
- Lynn E. Heasley,
- Robert L. Ferris,
- Olga Rodriguez,
- Christopher Albanese,
- Mohit Kapoor,
- Elena B. Pasquale,
- Sana D. Karam
Affiliations
- Shilpa Bhatia
- Department of Radiation Oncology, University of Colorado Denver
- Diemmy Nguyen
- Department of Radiation Oncology, University of Colorado Denver
- Laurel B. Darragh
- Department of Radiation Oncology, University of Colorado Denver
- Benjamin Van Court
- Department of Radiation Oncology, University of Colorado Denver
- Jaspreet Sharma
- Department of Radiation Oncology, University of Colorado Denver
- Michael W. Knitz
- Department of Radiation Oncology, University of Colorado Denver
- Miles Piper
- Department of Radiation Oncology, University of Colorado Denver
- Sanjana Bukkapatnam
- Department of Radiation Oncology, University of Colorado Denver
- Jacob Gadwa
- Department of Radiation Oncology, University of Colorado Denver
- Thomas E. Bickett
- Department of Radiation Oncology, University of Colorado Denver
- Shiv Bhuvane
- Department of Radiation Oncology, University of Colorado Denver
- Sophia Corbo
- Department of Radiation Oncology, University of Colorado Denver
- Brian Wu
- Krembil Research Institute, University Health Network and University of Toronto
- Yichien Lee
- Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
- Mayumi Fujita
- Department of Dermatology, University of Colorado Denver, Anschutz Medical Campus
- Molishree Joshi
- Department of Pharmacology, University of Colorado Denver, Anschutz Medical Campus
- Lynn E. Heasley
- Department of Craniofacial Biology, School of Dental Medicine, University of Colorado Denver
- Robert L. Ferris
- Department of Otolaryngology, University of Pittsburgh
- Olga Rodriguez
- Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
- Christopher Albanese
- Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center
- Mohit Kapoor
- Krembil Research Institute, University Health Network and University of Toronto
- Elena B. Pasquale
- Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Sana D. Karam
- Department of Radiation Oncology, University of Colorado Denver
- DOI
- https://doi.org/10.1038/s41467-022-31124-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
EphrinB2 and its receptor EphB4 are highly expressed in head and neck squamous cell carcinoma (HNSCC) and disrupting EphB4-ephrinB2 interaction generates sub-optimal outcomes. Here, compartmental targeting of EphB4 and ephrinB2 in HNSCC cancer cell and endothelial compartments suggests that ephrinB2 acts as a tumor promoter and EphB4 as a tumor suppressor.
