Nature Communications (Aug 2022)
BNT162b2-boosted immune responses six months after heterologous or homologous ChAdOx1nCoV-19/BNT162b2 vaccination against COVID-19
- Georg M. N. Behrens,
- Joana Barros-Martins,
- Anne Cossmann,
- Gema Morillas Ramos,
- Metodi V. Stankov,
- Ivan Odak,
- Alexandra Dopfer-Jablonka,
- Laura Hetzel,
- Miriam Köhler,
- Gwendolyn Patzer,
- Christoph Binz,
- Christiane Ritter,
- Michaela Friedrichsen,
- Christian Schultze-Florey,
- Inga Ravens,
- Stefanie Willenzon,
- Anja Bubke,
- Jasmin Ristenpart,
- Anika Janssen,
- George Ssebyatika,
- Verena Krähling,
- Günter Bernhardt,
- Markus Hoffmann,
- Stefan Pöhlmann,
- Thomas Krey,
- Berislav Bošnjak,
- Swantje I. Hammerschmidt,
- Reinhold Förster
Affiliations
- Georg M. N. Behrens
- Department for Rheumatology and Immunology, Hannover Medical School
- Joana Barros-Martins
- Institute of Immunology, Hannover Medical School
- Anne Cossmann
- Department for Rheumatology and Immunology, Hannover Medical School
- Gema Morillas Ramos
- Department for Rheumatology and Immunology, Hannover Medical School
- Metodi V. Stankov
- Department for Rheumatology and Immunology, Hannover Medical School
- Ivan Odak
- Institute of Immunology, Hannover Medical School
- Alexandra Dopfer-Jablonka
- Department for Rheumatology and Immunology, Hannover Medical School
- Laura Hetzel
- Department for Rheumatology and Immunology, Hannover Medical School
- Miriam Köhler
- Institute of Immunology, Hannover Medical School
- Gwendolyn Patzer
- Institute of Immunology, Hannover Medical School
- Christoph Binz
- Institute of Immunology, Hannover Medical School
- Christiane Ritter
- Institute of Immunology, Hannover Medical School
- Michaela Friedrichsen
- Institute of Immunology, Hannover Medical School
- Christian Schultze-Florey
- Institute of Immunology, Hannover Medical School
- Inga Ravens
- Institute of Immunology, Hannover Medical School
- Stefanie Willenzon
- Institute of Immunology, Hannover Medical School
- Anja Bubke
- Institute of Immunology, Hannover Medical School
- Jasmin Ristenpart
- Institute of Immunology, Hannover Medical School
- Anika Janssen
- Institute of Immunology, Hannover Medical School
- George Ssebyatika
- Institute of Biochemistry, University of Lübeck
- Verena Krähling
- Institute of Virology, Philipps University Marburg
- Günter Bernhardt
- Institute of Immunology, Hannover Medical School
- Markus Hoffmann
- Infection Biology Unit, German Primate Center
- Stefan Pöhlmann
- Infection Biology Unit, German Primate Center
- Thomas Krey
- Institute of Biochemistry, University of Lübeck
- Berislav Bošnjak
- Institute of Immunology, Hannover Medical School
- Swantje I. Hammerschmidt
- Institute of Immunology, Hannover Medical School
- Reinhold Förster
- German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig
- DOI
- https://doi.org/10.1038/s41467-022-32527-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
Vaccines against SARS-CoV-2 have changed the course of the COVID-19 pandemics, but waning immunity necessitates repeated immunization. Authors here show that immunity declines faster following two doses of vector-based vaccine compared to a first dose of vector-based vaccine followed by boosting with an mRNA vaccine, but application of an mRNA vaccine as a third dose minimises the difference between the two groups.
