Frontiers in Neurology (Dec 2018)

A Patient With Thiamine Deficiency Exhibiting Muscle Edema Suggested by MRI

  • Kenichiro Murate,
  • Yasuaki Mizutani,
  • Toshiki Maeda,
  • Ryunosuke Nagao,
  • Kouichi Kikuchi,
  • Sayuri Shima,
  • Yoshiki Niimi,
  • Akihiro Ueda,
  • Shinji Ito,
  • Tatsuro Mutoh

DOI
https://doi.org/10.3389/fneur.2018.01083
Journal volume & issue
Vol. 9

Abstract

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Myalgia is sometimes observed in patients with thiamine-deficiency neuropathy. However, the detailed mechanism(s) underlying muscular manifestations have been poorly elucidated. We herein report a possible patient with thiamine-deficiency neuropathy exhibiting muscle weakness and myalgia in lower limbs. The patient exhibited abnormal muscle signal intensities on MRI corresponding to the site of myalgia. After thiamine replacement therapy, rapid improvement of clinical symptoms and abnormal MRI findings were observed. Muscle MRI findings in this case implicated the possible mechanism of myalgia observed in patients with thiamine deficiency neuropathy.

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