Nature Communications (Nov 2021)
AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway
- Hoi Yin Mak,
- Qian Ouyang,
- Sergey Tumanov,
- Jiesi Xu,
- Ping Rong,
- Feitong Dong,
- Sin Man Lam,
- Xiaowei Wang,
- Ivan Lukmantara,
- Ximing Du,
- Mingming Gao,
- Andrew J. Brown,
- Xin Gong,
- Guanghou Shui,
- Roland Stocker,
- Xun Huang,
- Shuai Chen,
- Hongyuan Yang
Affiliations
- Hoi Yin Mak
- School of Biotechnology and Biomolecular Sciences, the University of New South Wales
- Qian Ouyang
- MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, School of Medicine, Nanjing University
- Sergey Tumanov
- Heart Research Institute, The University of Sydney
- Jiesi Xu
- State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
- Ping Rong
- MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, School of Medicine, Nanjing University
- Feitong Dong
- Department of Biology, Southern University of Science and Technology
- Sin Man Lam
- State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
- Xiaowei Wang
- Laboratory of Lipid Metabolism, Hebei Medical University
- Ivan Lukmantara
- School of Biotechnology and Biomolecular Sciences, the University of New South Wales
- Ximing Du
- School of Biotechnology and Biomolecular Sciences, the University of New South Wales
- Mingming Gao
- Laboratory of Lipid Metabolism, Hebei Medical University
- Andrew J. Brown
- School of Biotechnology and Biomolecular Sciences, the University of New South Wales
- Xin Gong
- Department of Biology, Southern University of Science and Technology
- Guanghou Shui
- State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
- Roland Stocker
- Heart Research Institute, The University of Sydney
- Xun Huang
- State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
- Shuai Chen
- MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, School of Medicine, Nanjing University
- Hongyuan Yang
- School of Biotechnology and Biomolecular Sciences, the University of New South Wales
- DOI
- https://doi.org/10.1038/s41467-021-27279-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
AGPATs (1-acylglycerol-3-phosphate O-acyltransferases) catalyze the acylation of lysophosphatidic acid to form phosphatidic acid (PA), a key step in the synthesis of all glycerolipids. Here, the authors show that AGPAT2 and CDP-DAG synthases (CDS1 and CDS2) form functional complexes that promote further conversion of PA along the CDP-DAG pathway of phospholipid synthesis.
