Nature Communications (May 2016)

EB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule lattice

  • Geethu E. Thomas,
  • K. Bandopadhyay,
  • Sabyasachi Sutradhar,
  • M. R. Renjith,
  • Puja Singh,
  • K. K. Gireesh,
  • Steny Simon,
  • Binshad Badarudeen,
  • Hindol Gupta,
  • Manidipa Banerjee,
  • Raja Paul,
  • J. Mitra,
  • Tapas K. Manna

DOI
https://doi.org/10.1038/ncomms11665
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

Read online

Ska1 is a kinetochore-localised protein that couples kinetochore movement to microtubule (MT) depolymerisation. Here Thomas et al. show that the MT +TIP binding protein EB1 recruits Ska1 to the MT-kinetochore interface and stabilises the interaction between Ska1 and MTs.