Menopause Review (Jun 2010)
Ekspresja białek Id1, epidermalnego czynnika wzrostu (EGF) i jego receptora (EGF-R) w nowotworach złośliwych jajnika
Abstract
Introduction: Inhibitors of DNA binding/inhibitors of differentiation (Id) protein family (Id1, Id2, Id3 and Id4)may play an important role in various cancer angiogenesis stimulation through interactions with strongmitogenic and angiogenic factors such as EGF and EGFR.Aim of the study: Our aim was to assess if the expression of Id1 protein with EGF and EGF-R serumconcentration assessment is associated with selected epidemiological, clinical and histological features ofmalignant ovarian tumours.Material and methods: The study group included 95 women operated because of ovarian tumours. In thisgroup, 83 masses proved to be malignant. The findings were correlated with the tumour type, histologicalgrading and tumour FIGO stage. Tumour Id1 protein was assessed by immunohistochemistry and EGF with EGF-Rserum concentrations were examined by ELISA.Results: The mean age of the patients was 52.6 ±15.1 years and 43 (45.2%) of women in this group werepremenopausal. Histological examination revealed that in the malignant group there were 38 serous ovariancancers, 23 mucinous cancers, 7 endometrioid cancers and 13 other malignant tumours including 6 metastaticto the ovary. Significant differences were found between concentrations of EGF and EGF-R depending on thepatient's menopausal status (p = 0.01 and p = 0.002, respectively). Histological grade was significantlycorrelated with EGF concentrations in women with malignant ovarian tumours (p = 0.01). FIGO stage was alsosignificantly correlated with Id1 expression (p = 0.09) and EGF concentration (p = 0.01). Also, significantcorrelations were found between Id1 expression, and histological grade and tumour FIGO stage (both p = 0.005). EGF and EGF-R concentrations were significantly correlated with each other (p = 0.008). Moreover, both EGF andEGF-R concentrations were correlated with Id1 expression (p = 0.0005 and p = 0.004, respectively).Conclusion: Our results indicate that Id1 protein and EGF with EGF-R concentration assessment may beused as additional prognostic markers in women with various types of malignant ovarian tumours.
