TLR4 is a regulator of trained immunity in a murine model of Duchenne muscular dystrophy

Salyan Bhattarai; Qian Li; Jun Ding; Feng Liang; Ekaterina Gusev; Orsolya Lapohos; Gregory J. Fonseca; Eva Kaufmann; Maziar Divangahi; Basil J. Petrof

doi:10.1038/s41467-022-28531-1

Nature Communications (Feb 2022)

TLR4 is a regulator of trained immunity in a murine model of Duchenne muscular dystrophy

Salyan Bhattarai,
Qian Li,
Jun Ding,
Feng Liang,
Ekaterina Gusev,
Orsolya Lapohos,
Gregory J. Fonseca,
Eva Kaufmann,
Maziar Divangahi,
Basil J. Petrof

Affiliations

Salyan Bhattarai: Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
Qian Li: Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
Jun Ding: Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
Feng Liang: Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
Ekaterina Gusev: Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
Orsolya Lapohos: Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
Gregory J. Fonseca: Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
Eva Kaufmann: Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
Maziar Divangahi: Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre
Basil J. Petrof: Meakins-Christie Laboratories, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre

DOI: https://doi.org/10.1038/s41467-022-28531-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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The immunopathology of Duchenne Muscular Dystrophy includes a disturbed balance of pro and anti-inflammatory macrophages. Here the authors implicate trained innate immunity in a murine model of the disease, and reveal TLR4 as a key regulator of this process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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