Nature Communications (Nov 2022)

Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission

  • Tianyang Liu,
  • Fiona Shilliday,
  • Alexander D. Cook,
  • Mohammad Zeeshan,
  • Declan Brady,
  • Rita Tewari,
  • Colin J. Sutherland,
  • Anthony J. Roberts,
  • Carolyn A. Moores

DOI
https://doi.org/10.1038/s41467-022-34710-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

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Plasmodium kinesin-8B is essential for male gamete formation and its absence blocks parasite transmission. Using cryo-EM and TIRF, the authors report how kinesin-8B motor domains are tuned to support microtubule motility and depolymerase activity.