PLoS ONE (Jan 2014)

Serum bilirubin affects graft outcomes through UDP-glucuronosyltransferase sequence variation in kidney transplantation.

  • Jung Pyo Lee,
  • Do Hyoung Kim,
  • Seung Hee Yang,
  • Jin Ho Hwang,
  • Jung Nam An,
  • Sang Il Min,
  • Jongwon Ha,
  • Yun Kyu Oh,
  • Yon Su Kim,
  • Chun Soo Lim

DOI
https://doi.org/10.1371/journal.pone.0093633
Journal volume & issue
Vol. 9, no. 4
p. e93633

Abstract

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BackgroundOxidative stress is a major mediator of adverse outcome after kidney transplantation. Bilirubin is produced by heme oxygenase-1 (HO-1), catalyzed by UDP-glucuronosyltransferase (UGT1A1), and has potential as an antioxidant. In this study, we investigated the effects of HO-1 and UGT1A1 sequence variations on kidney allograft outcomes.MethodsClinical data were collected from 429 Korean recipients who underwent kidney transplantation from 1990-2008. Genotyping for UGT1A1*28 and HO-1 (A-413T) was performed. Acute rejection and graft survival were monitored as end-points.ResultsSerum levels of total bilirubin were significantly increased after transplantation (0.41 ± 0.19 mg/dL to 0.80 ± 0.33 mg/dL, PConclusionsThe UGT1A1*28 polymorphism is associated with changes in serum bilirubin and with graft outcome after kidney transplantation.