Powder Particles and Technologies for Medicine Delivery to the Respiratory System: Challenges and Opportunities

Abstract

The paper discusses essential engineering challenges related to the application of powder medicines for pulmonary delivery as inhaled aerosol. Starting from a physically based description of the complexity of aerosol dynamics inside the respiratory system, the paper discusses several technical factors responsible for efficient drug delivery to the lungs: (i) interparticle interactions—which can be tuned by selection and control of powder manufacturing methods, (ii) inhaler design—as a determinant of flow dynamics through the inhaling device and degree of powder dispersion, (iii) the dynamics of inhalation in a given inhaler—which is related to patient-device interaction. Basic information on the standard (compendial) methods of the quantitative evaluation of dry powder inhalers (DPIs) are presented with a special focus on the correct data interpretation and the consequences for in vivo-in vitro correlation (IVIVC) problems. Some issues regarding the development of inhalation products (including generics) are also briefly highlighted. Finally, possible strategies of powder particle functionalization to obtain the required bioavailability are outlined on the basis of knowledge on the physicochemical interactions of inhaled particles with the lung fluids.

Keywords

• inhalation
• lung deposition
• dpi
• flow dynamics
• mucus
• pulmonary surfactant