Nature Communications (Feb 2020)

The Ca2+ permeation mechanism of the ryanodine receptor revealed by a multi-site ion model

  • Aihua Zhang,
  • Hua Yu,
  • Chunhong Liu,
  • Chen Song

DOI
https://doi.org/10.1038/s41467-020-14573-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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Although the permeation mechanisms for K+ and Na+ channels have been extensively studied, the ion permeation mechanism through Ca2+ channels was largely unknown. Here the authors develop a multisite Ca2+ model that can be used in the framework of classical MD simulations to study Ca2+ in a quantitative manner, and use it to investigate the ion permeation mechanism of the ryanodine receptor 1.