Enhancement of anaerobic glycolysis – a role of PGC-1α4 in resistance exercise

Jin-Ho Koh; Mark W. Pataky; Surendra Dasari; Katherine A. Klaus; Ivan Vuckovic; Gregory N. Ruegsegger; Arathi Prabha Kumar; Matthew M. Robinson; K. Sreekumaran Nair

doi:10.1038/s41467-022-30056-6

Nature Communications (Apr 2022)

Enhancement of anaerobic glycolysis – a role of PGC-1α4 in resistance exercise

Jin-Ho Koh,
Mark W. Pataky,
Surendra Dasari,
Katherine A. Klaus,
Ivan Vuckovic,
Gregory N. Ruegsegger,
Arathi Prabha Kumar,
Matthew M. Robinson,
K. Sreekumaran Nair

Affiliations

Jin-Ho Koh: Division of Endocrinology and Metabolism, Mayo Clinic
Mark W. Pataky: Division of Endocrinology and Metabolism, Mayo Clinic
Surendra Dasari: Department of Health Sciences Research, Mayo Clinic
Katherine A. Klaus: Division of Endocrinology and Metabolism, Mayo Clinic
Ivan Vuckovic: Mayo Clinic Regional Comprehensive Metabolomics Core, Mayo Clinic
Gregory N. Ruegsegger: Division of Endocrinology and Metabolism, Mayo Clinic
Arathi Prabha Kumar: Division of Endocrinology and Metabolism, Mayo Clinic
Matthew M. Robinson: School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University
K. Sreekumaran Nair: Division of Endocrinology and Metabolism, Mayo Clinic

DOI: https://doi.org/10.1038/s41467-022-30056-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Resistance exercise training (RET) is an effective countermeasure to sarcopenia, related frailty and metabolic disorders. Here, the authors show that an RET-induced increase in PGC-1α4 expression not only promotes muscle hypertrophy but also enhances glycolysis, providing a rapid supply of ATP for muscle contractions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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