Nature Communications (Aug 2022)

Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose

  • Laurent Renia,
  • Yun Shan Goh,
  • Angeline Rouers,
  • Nina Le Bert,
  • Wan Ni Chia,
  • Jean-Marc Chavatte,
  • Siew‐Wai Fong,
  • Zi Wei Chang,
  • Nicole Ziyi Zhuo,
  • Matthew Zirui Tay,
  • Yi-Hao Chan,
  • Chee Wah Tan,
  • Nicholas Kim‐Wah Yeo,
  • Siti Naqiah Amrun,
  • Yuling Huang,
  • Joel Xu En Wong,
  • Pei Xiang Hor,
  • Chiew Yee Loh,
  • Bei Wang,
  • Eve Zi Xian Ngoh,
  • Siti Nazihah Mohd Salleh,
  • Guillaume Carissimo,
  • Samanzer Dowla,
  • Alicia Jieling Lim,
  • Jinyan Zhang,
  • Joey Ming Er Lim,
  • Cheng-I. Wang,
  • Ying Ding,
  • Surinder Pada,
  • Louisa Jin Sun,
  • Jyoti Somani,
  • Eng Sing Lee,
  • Desmond Luan Seng Ong,
  • SCOPE Cohort Study Group,
  • Yee‐Sin Leo,
  • Paul A. MacAry,
  • Raymond Tzer Pin Lin,
  • Lin-Fa Wang,
  • Ee Chee Ren,
  • David C. Lye,
  • Antonio Bertoletti,
  • Barnaby Edward Young,
  • Lisa F. P. Ng

DOI
https://doi.org/10.1038/s41467-022-32312-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

Read online

Responses to SARS-CoV-2 vaccines in different populations are important to define efficacy. Here the authors show using a cohort in Singapore that two doses of mRNA vaccine is less effective in recipients over 60 years of age and that a further dose of vaccine can improve these antibody levels.