Triarylmethyl Cation Catalysis: A Tunable Lewis Acid Organo­catalyst for the Synthesis of Bisindolylmethanes

Abstract

Abstract Triarylmethyl cations serve as tunable organocatalysts for the synthesis of bisindolylmethanes. The catalyst structure can be modified to increase or decrease reactivity as needed to match the requirements of the substrate. High yields are achieved for a variety of substrates by using these green catalysts. Catalyst tuning allows for the use of less reactive electrophiles by increasing the reactivity of the catalyst. Acid-sensitive products can be isolated under these mild reaction conditions.

Keywords

• antibiotics
• carbocation
• catalysis
• electrophilic aromatic substitution
• green chemistry
• indoles
• lewis acids