Innovative Metal-Organic Frameworks for Targeted Oral Cancer Therapy: A Review
Seyyed Mojtaba Mousavi,
Seyyed Alireza Hashemi,
Fatemeh Fallahi Nezhad,
Mojtaba Binazadeh,
Milad Dehdashtijahromi,
Navid Omidifar,
Yasamin Ghahramani,
Chin Wei Lai,
Wei-Hung Chiang,
Ahmad Gholami
Affiliations
Seyyed Mojtaba Mousavi
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan
Seyyed Alireza Hashemi
Nanomaterials and Polymer Nanocomposites Laboratory, School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada
Fatemeh Fallahi Nezhad
Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz 71439-14693, Iran
Mojtaba Binazadeh
Department of Chemical Engineering, School of Chemical and Petroleum Engineering, Shiraz 71557-13876, Iran
Milad Dehdashtijahromi
Department of Chemical Engineering, School of Chemical and Petroleum Engineering, Shiraz 71557-13876, Iran
Navid Omidifar
Department of Pathology, Shiraz University of Medical Sciences, Shiraz 71439-14693, Iran
Yasamin Ghahramani
Associate Professor of Endodontics Department of Endodontics, School of Dentistry Oral and Dental Disease Research Center Shiraz University of Medical Sciences, Shiraz 71956-15787, Iran
Chin Wei Lai
Nanotechnology & Catalysis Research Centre (NANOCAT), University of Malaya (UM), Kuala Lumpur 50603, Malaysia
Wei-Hung Chiang
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan
Ahmad Gholami
Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz 71439-14693, Iran
Metal-organic frameworks (MOFs) have proven to be very effective carriers for drug delivery in various biological applications. In recent years, the development of hybrid nanostructures has made significant progress, including developing an innovative MOF-loaded nanocomposite with a highly porous structure and low toxicity that can be used to fabricate core-shell nanocomposites by combining complementary materials. This review study discusses using MOF materials in cancer treatment, imaging, and antibacterial effects, focusing on oral cancer cells. For patients with oral cancer, we offer a regular program for accurately designing and producing various anticancer and antibacterial agents to achieve maximum effectiveness and the lowest side effects. Also, we want to ensure that the anticancer agent works optimally and has as few side effects as possible before it is tested in vitro and in vivo. It is also essential that new anticancer drugs for cancer treatment are tested for efficacy and safety before they go into further research.
