Immune-checkpoint protein VISTA in allergic, autoimmune disease and transplant rejection

Meijun Zheng; Zongliang Zhang; Lingyu Yu; Zeng Wang; Yijun Dong; Aiping Tong; Hui Yang

doi:10.3389/fimmu.2023.1194421

Frontiers in Immunology (Jun 2023)

Immune-checkpoint protein VISTA in allergic, autoimmune disease and transplant rejection

Meijun Zheng,
Zongliang Zhang,
Lingyu Yu,
Zeng Wang,
Yijun Dong,
Aiping Tong,
Hui Yang

Affiliations

Meijun Zheng: Department of Otolaryngology, Head and Neck Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China
Zongliang Zhang: State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, Chengdu, Sichuan, China
Lingyu Yu: Department of Otolaryngology, Head and Neck Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China
Zeng Wang: State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, Chengdu, Sichuan, China
Yijun Dong: Department of Otolaryngology, Head and Neck Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China
Aiping Tong: State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, Chengdu, Sichuan, China
Hui Yang: Department of Otolaryngology, Head and Neck Surgery, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China

DOI: https://doi.org/10.3389/fimmu.2023.1194421
Journal volume & issue: Vol. 14

Abstract

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Negative checkpoint regulators (NCRs) reduce the T cell immune response against self-antigens and limit autoimmune disease development. V-domain Ig suppressor of T cell activation (VISTA), a novel immune checkpoint in the B7 family, has recently been identified as one of the NCRs. VISTA maintains T cell quiescence and peripheral tolerance. VISTA targeting has shown promising results in treating immune-related diseases, including cancer and autoimmune disease. In this review, we summarize and discuss the immunomodulatory role of VISTA, its therapeutic potential in allergic, autoimmune disease, and transplant rejection, as well as the current therapeutic antibodies, to present a new method for regulating immune responses and achieving durable tolerance for the treatment of autoimmune disease and transplantation.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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Abstract

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