PLoS Neglected Tropical Diseases (Feb 2021)

Effects of steroid therapy in patients with severe fever with Thrombocytopenia syndrome: A multicenter clinical cohort study.

  • Sook In Jung,
  • Ye Eun Kim,
  • Na Ra Yun,
  • Choon-Mee Kim,
  • Dong-Min Kim,
  • Mi Ah Han,
  • Uh Jin Kim,
  • Seong Eun Kim,
  • Jieun Kim,
  • Seong Yeol Ryu,
  • Hyun Ah Kim,
  • Jian Hur,
  • Young Keun Kim,
  • Hye Won Jeong,
  • Jung Yeon Heo,
  • Dong Sik Jung,
  • Hyungdon Lee,
  • Kyungmin Huh,
  • Yee Gyung Kwak,
  • Sujin Lee,
  • Seungjin Lim,
  • Sun Hee Lee,
  • Sun Hee Park,
  • Joon-Sup Yeom,
  • Shin-Woo Kim,
  • In-Gyu Bae,
  • Juhyung Lee,
  • Eu Suk Kim,
  • Jun-Won Seo

DOI
https://doi.org/10.1371/journal.pntd.0009128
Journal volume & issue
Vol. 15, no. 2
p. e0009128

Abstract

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BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an acute, febrile, and potentially fatal tick-borne disease caused by the SFTS Phlebovirus. Here, we evaluated the effects of steroid therapy in Korean patients with SFTS.MethodsA retrospective study was performed in a multicenter SFTS clinical cohort from 13 Korean university hospitals between 2013 and 2017. We performed survival analysis using propensity score matching of 142 patients with SFTS diagnosed by genetic or antibody tests.ResultsOverall fatality rate was 23.2%, with 39.7% among 58 patients who underwent steroid therapy. Complications were observed in 37/58 (63.8%) and 25/83 (30.1%) patients in the steroid and non-steroid groups, respectively (P 5 days), and non-steroid groups, were 18.4, 22.4, and 27.3 days, respectively (P = .005).ConclusionsAfter steroid therapy, an increase in complications was observed among patients with SFTS. Steroid therapy should be used with caution, considering the possible negative effects of steroid therapy within 5 days of symptom onset or in patients with mild disease (APACHE II score <14).