Protease-controlled secretion and display of intercellular signals

Alexander E. Vlahos; Jeewoo Kang; Carlos A. Aldrete; Ronghui Zhu; Lucy S. Chong; Michael B. Elowitz; Xiaojing J. Gao

doi:10.1038/s41467-022-28623-y

Nature Communications (Feb 2022)

Protease-controlled secretion and display of intercellular signals

Alexander E. Vlahos,
Jeewoo Kang,
Carlos A. Aldrete,
Ronghui Zhu,
Lucy S. Chong,
Michael B. Elowitz,
Xiaojing J. Gao

Affiliations

Alexander E. Vlahos: Department of Chemical Engineering, Stanford University
Jeewoo Kang: Neurosciences Interdepartmental Program, Stanford University
Carlos A. Aldrete: Department of Chemical Engineering, Stanford University
Ronghui Zhu: Howard Hughes Medical Institute, Division of Biology and Biological Engineering, California Institute of Technology
Lucy S. Chong: Howard Hughes Medical Institute, Division of Biology and Biological Engineering, California Institute of Technology
Michael B. Elowitz: Howard Hughes Medical Institute, Division of Biology and Biological Engineering, California Institute of Technology
Xiaojing J. Gao: Department of Chemical Engineering, Stanford University

DOI: https://doi.org/10.1038/s41467-022-28623-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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To program intercellular communication for biomedicine, it is crucial to regulate the secretion and surface display of signaling proteins. Here the authors develop RELEASE, a modular approach to control intercellular signals using protein-based circuits.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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